TargetMol

Coformycin

Product Code:
 
TAR-T23905
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T23905-5mg5mg£850.00
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Further Information

Bioactivity:
Coformycin is a ribonucleoside antibiotic synergist and adenosine deaminase inhibitor.
CAS:
11033-22-0
Formula:
C11H16N4O5
Molecular Weight:
284.272
Purity:
0.98
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2[C@H](O)CN=CNc12

References

1. Bzowska A, Lassota P, Shugar D. Phosphorylation of coformycin and 2'-deoxycoformycin, and substrate and inhibitor properties of the nucleosides and nucleotides in several enzyme systems. Z Naturforsch C. 1985 Sep-Oct;40(9-10):710-4. PubMed PMID: 3002059. 2. Hanvey JC, Hawkins ES, Baker DC, Suhadolnik RJ. 8-Ketodeoxycoformycin and 8-ketocoformycin as intermediates in the biosynthesis of 2'-deoxycoformycin and coformycin. Biochemistry. 1988 Jul 26;27(15):5790-5. PubMed PMID: 3052586. 3. Danton MJ, Coleman MS. Isolation of mutant adenosine deaminase by coformycin affinity chromatography. Anal Biochem. 1986 Nov 15;159(1):233-9. PubMed PMID: 3492941. 4. Han BW, Bingman CA, Mahnke DK, Sabina RL, Phillips GN Jr. Crystallization and preliminary X-ray crystallographic analysis of adenosine 5'-monophosphate deaminase (AMPD) from Arabidopsis thaliana in complex with coformycin 5'-phosphate. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Aug 1;61(Pt 8):740-2. Epub 2005 Jul 8. PubMed PMID: 16511144; PubMed Central PMCID: PMC1952363.