TargetMol

Buformin

Product Code:
 
TAR-T23837
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23837-5mg5mg£850.00
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Quantity:
TAR-T23837-50mg50mg£1,661.00
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Quantity:
TAR-T23837-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class. It also inhibits the synthesis of glucose by the liver. Buformin delays absorption of glucose from the gastrointestinal tract increases insulin sensitivity and glucose uptake into cells.
CAS:
692-13-7
Formula:
C6H15N5
Molecular Weight:
157.22
Purity:
0.98
SMILES:
N=C(NC(N)=N)NCCCC

References

1. Li J, Chen L, Liu Q, Tang M, Wang Y, Yu J. Buformin suppresses proliferation and invasion via AMPK/S6 pathway in cervical cancer and synergizes with paclitaxel. Cancer Biol Ther. 2018 Jun 3;19(6):507-517. doi: 10.1080/15384047.2018.1433504. Epub 2018 Feb 27. PubMed PMID: 29400636; PubMed Central PMCID: PMC5927663. 2. Alshishani A, Salhimi SM, Saad B. Salting-out assisted liquid-liquid extraction coupled with hydrophilic interaction chromatography for the determination of biguanides in biological and environmental samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 15;1073:51-59. doi: 10.1016/j.jchromb.2017.12.013. Epub 2017 Dec 9. PubMed PMID: 29241085. 3. Bailey CJ. Metformin: historical overview. Diabetologia. 2017 Sep;60(9):1566-1576. doi: 10.1007/s00125-017-4318-z. Epub 2017 Aug 3. PubMed PMID: 28776081. 4. Gabel SA, Duff MR, Pedersen LC, DeRose EF, Krahn JM, Howell EE, London RE. A Structural Basis for Biguanide Activity. Biochemistry. 2017 Sep 12;56(36):4786-4798. doi: 10.1021/acs.biochem.7b00619. Epub 2017 Aug 29. PubMed PMID: 28766937; PubMed Central PMCID: PMC5740485.