TargetMol

alphaSYN-IN-NAB2

Product Code:
 
TAR-T23709
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23709-1mg1mg£146.00
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TAR-T23709-5mg5mg£251.00
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TAR-T23709-10mg10mg£342.00
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TAR-T23709-25mg25mg£505.00
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TAR-T23709-50mg50mg£695.00
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TAR-T23709-100mg100mg£946.00
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Quantity:
TAR-T23709-500mg500mg£1,821.00
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Further Information

Bioactivity:
alphaSYN-IN-NAB2 is an α-synuclein mutations inhibitor that acts by reversing the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons and promoting E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.
CAS:
1504588-00-4
Formula:
C23H20ClN3O
Molecular Weight:
389.88
Purity:
0.98
SMILES:
Cc1ccc(C)c(c1)-n1cnc2cc(ccc12)C(=O)NCc1ccccc1Cl

References

1. Wang L, Hong J, Wu Y, Liu G, Yu W, Chen L. Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of ?-synuclein and neuroinflammation. Cell Death Dis. 2018 Apr 18;9(5):440. doi: 10.1038/s41419-018-0471-7. PubMed PMID: 29670081. 2. Shvadchak VV, Afitska K, Yushchenko DA. Inhibition of ?-Synuclein Amyloid Fibril Elongation by Blocking Fibril Ends. Angew Chem Int Ed Engl. 2018 Mar 25. doi: 10.1002/anie.201801071. [Epub ahead of print] PubMed PMID: 29575453. 3. Sturm E, Fellner L, Krismer F, Poewe W, Wenning GK, Stefanova N. Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy. Neurotherapeutics. 2016 Oct;13(4):871-879. doi: 10.1007/s13311-016-0447-1. PubMed PMID: 27259295; PubMed Central PMCID: PMC5081120. 4. Delenclos M, Trendafilova T, Jones DR, Moussaud S, Baine AM, Yue M, Hirst WD, McLean PJ. A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo. Front Neurosci. 2016 Jan 19;9:511. doi: 10.3389/fnins.2015.00511. eCollection 2015. PubMed PMID: 26834539; PubMed Central PMCID: PMC4717311.