TargetMol

GSK2334470

Product Code:
 
TAR-T2348
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2348-5mg5mg£109.00
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TAR-T2348-10mg10mg£134.00
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TAR-T2348-1mL1 mL * 10 mM (in DMSO)£140.00
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TAR-T2348-25mg25mg£189.00
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TAR-T2348-50mg50mg£288.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.
CAS:
1227911-45-6
Formula:
C25H34N8O
Molecular Weight:
462.602
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.9865
SMILES:
CNc1nc(cc(n1)-c1ccc2c(N)n[nH]c2c1)N1C[C@H](CC[C@H]1C)C(=O)NC1CCCCC1
Target:
PDK

References

1. Najafov A, et al. Biochem J, 2011, 433(2), 357-369. 2. Artamonov M, et al. PLoS One, 2013, 8(3), e58703. 3. Raimondi C, et al. J Cell Sci, 2012, 125(Pt 13), 3153-3163. 4. Scortegagna M, et al. Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma. Oncogene. 2014 Aug 21;33(34):4330-9.