TargetMol

Pentamidine dihydrochloride

Product Code:
 
TAR-T23132
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23132-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T23132-5mg5mg£111.00
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TAR-T23132-10mg10mg£131.00
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TAR-T23132-25mg25mg£173.00
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TAR-T23132-50mg50mg£225.00
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TAR-T23132-100mg100mg£301.00
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TAR-T23132-200mg200mg£417.00
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TAR-T23132-500mg500mg£643.00
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This product comes from: United States.
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Further Information

Bioactivity:
Pentamidine dihydrochloride is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases and phosphatase of regenerating liver inhibitor. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM.
CAS:
50357-45-4
Formula:
C19H26Cl2N4O2
Molecular Weight:
413.34
Pathway:
Microbiology/Virology; Metabolism
Purity:
0.98
SMILES:
[Cl-].[Cl-].NC(=[NH2+])c1ccc(OCCCCCOc2ccc(cc2)C(N)=[NH2+])cc1
Target:
Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal

References

1. Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400. 2. David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49. 3. Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64. 4. Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34.