TargetMol

1-Deoxymannojirimycin hydrochloride

Product Code:
 
TAR-T22468
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
1-Deoxymannojirimycin hydrochloride is a selective α1,2-mannosidase inhibitor(IC50: 20 μM). 1-Deoxymannojirimycin hydrochloride also inhibits HIV?1 strains and has poor antiviral activity.
CAS:
73465-43-7
Formula:
C6H14ClNO4
Molecular Weight:
199.63
Pathway:
Proteases/Proteasome; Microbiology/Virology;
Purity:
0.98
SMILES:
Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O
Target:
Influenza Virus; HIV Protease

References

1. Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4. 2. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98.