TargetMol

WP1066

Product Code:
 
TAR-T2156
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2156-5mg5mg£106.00
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TAR-T2156-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T2156-10mg10mg£130.00
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TAR-T2156-25mg25mg£177.00
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TAR-T2156-50mg50mg£251.00
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TAR-T2156-100mg100mg£324.00
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Quantity:
TAR-T2156-500mg500mg£687.00
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Further Information

Bioactivity:
WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3. WP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Central Nervous System Neoplasms.
CAS:
857064-38-1
Formula:
C17H14BrN3O
Molecular Weight:
356.223
Pathway:
Stem Cells; Chromatin/Epigenetic; Angiogenesis; JAK/STAT signaling; Apoptosis
Purity:
0.9907
SMILES:
C[C@H](NC(=O)C(=Cc1cccc(Br)n1)C#N)c1ccccc1
Target:
Apoptosis; JAK; STAT

References

1. Verstovsek S, et al. Clin Cancer Res, 2008, (3), 788-796. 2. Hatiboglu MA, et al. Int J Cancer, 2012, 131(1), 8-17 3. Ferrajoli A, et al. Cancer Res, 2007, 67(23), 11291-11299. 4. Horiguchi A, et al. Br J Cancer, 2010, 102(11), 1592-1599. 5. Li M, Yu H. Identification of WP1066, an inhibitor of JAK2 and STAT3, as a Kv1. 3 potassium channel blocker[J].?. British Journal of Pharmacology. 2021