TargetMol

BIX02189

Product Code:
 
TAR-T21295
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21295-1mg1mg£98.00
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TAR-T21295-5mg5mg£132.00
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TAR-T21295-1mL1 mL * 10 mM (in DMSO)£141.00
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TAR-T21295-10mg10mg£164.00
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TAR-T21295-25mg25mg£242.00
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TAR-T21295-50mg50mg£367.00
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TAR-T21295-100mg100mg£511.00
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This product comes from: United States.
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Further Information

Bioactivity:
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).
CAS:
1265916-41-3
Formula:
C27H28N4O2
Molecular Weight:
440.547
Pathway:
MAPK
Purity:
0.9917
SMILES:
CN(C)Cc1cccc(NC(=C2/C(=O)Nc3cc(ccc23)C(=O)N(C)C)c2ccccc2)c1
Target:
ERK; MEK

References

1. Tatake RJ, et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5. 2. Kim M, et al. Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation. J Biol Chem. 2012 Nov 23;287(48):40722-31. 3. Hwang AR, et al. Fluvastatin inhibits AGE-induced cell proliferation and migration via an ERK5-dependent Nrf2 pathway in vascular smooth muscle cells. PLoS One. 2017 May 22;12(5):e0178278.