TargetMol

Labetalol

Product Code:
 
TAR-T20570
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T20570-10mg10mg£104.00
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TAR-T20570-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T20570-25mg25mg£130.00
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TAR-T20570-50mg50mg£163.00
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TAR-T20570-100mg100mg£216.00
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This product comes from: United States.
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Further Information

Bioactivity:
Labetalol is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situations. The pharmacokinetics of labetalol is affected by the common CYP2C19 polymorphisms.
CAS:
36894-69-6
Formula:
C19H24N2O3
Molecular Weight:
328.412
Pathway:
Neuroscience; GPCR/G Protein
Purity:
0.9987
SMILES:
CC(CCc1ccccc1)NCC(O)c1ccc(O)c(c1)C(N)=O
Target:
Adrenergic Receptor

References

Fischer JH, Sarto GE, Hardman J, et al. Influence of gestational age and body weight on the pharmacokinetics of labetalol in pregnancy. Clin Pharmacokinet. 2014 Apr;53(4):373-83. doi: 10.1007/s40262-013-0123-0. PubMed PMID: 24297680; PubMed Central PMCID: PMC4310214. Liu-DeRyke X, Levy PD, Parker D Jr, Coplin W, Rhoney DH. A prospective evaluation of labetalol versus nicardipine for blood pressure management in patients with acute stroke. Neurocrit Care. 2013 Aug;19(1):41-7. doi: 10.1007/s12028-013-9863-9. PubMed PMID: 23760911. Lang Y, Fu F, Sun D, Xi C, Chen F. Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain Injury. PLoS One. 2015 Jul 17;10(7):e0133215. doi: 10.1371/journal.pone.0133215. eCollection 2015. PubMed PMID: 26186619; PubMed Central PMCID: PMC4505891. Chan SW, Hu M, Ko SS, Tam CW, Fok BS, Yin OQ, Chow MS, Tomlinson B. CYP2C19 genotype has a major influence on labetalol pharmacokinetics in healthy male Chinese subjects. Eur J Clin Pharmacol. 2013 Apr;69(4):799-806. doi: 10.1007/s00228-012-1428-x. Epub 2012 Oct 23. PubMed PMID: 23090703.