TargetMol

AG-1478

Product Code:
 
TAR-T2047
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2047-5mg5mg£107.00
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Quantity:
TAR-T2047-1mL1 mL * 10 mM (in DMSO)£111.00
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Quantity:
TAR-T2047-10mg10mg£119.00
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TAR-T2047-25mg25mg£162.00
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Quantity:
TAR-T2047-50mg50mg£237.00
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Quantity:
TAR-T2047-100mg100mg£302.00
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Quantity:
TAR-T2047-200mg200mg£371.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor.
CAS:
153436-53-4
Formula:
C16H14ClN3O2
Molecular Weight:
315.76
Pathway:
Proteases/Proteasome; JAK/STAT signaling; Tyrosine Kinase/Adaptors; Microbiology/Virology; Angiogenesis
Purity:
0.9971
SMILES:
COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
Target:
EGFR; HCV Protease; Influenza Virus; HER; PDGFR

References

1. Levitzki A, et al. Science, 1995, 267(5205), 1782-1788. 2. Han Y, et al. Cancer Res, 1996, 56(17), 3859-3861. 3. Eguchi S, et al. J Biol Chem, 1998, 273(15), 8890-8896. 4. Johns TG, et al. Proc Natl Acad Sci U S A, 2003, 100(26), 15871-15876. 5. Lee FT, et al. Clin Cancer Res, 2005, 11(19 Pt 2), 7080s-7086s. 6. Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215. 7. Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580. 8. Li S T, Young T H, Huang T W. Poly (ethylene-co-vinyl alcohol) is a suitable substrate for human olfactory neuroepithelial cell differentiation in vitro through a defined regulatory pathway[J]. Acta biomaterialia. 2018 Mar 1;68:204-213.