TargetMol

Phenformin

Product Code:
 
TAR-T20158
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T20158-25mg25mg£105.00
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Quantity:
TAR-T20158-5mg5mg£111.00
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TAR-T20158-50mg50mg£119.00
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TAR-T20158-100mg100mg£142.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Phenformin is an antidiabetic drug from the biguanide class. It is A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN.
CAS:
114-86-3
Formula:
C10H15N5
Molecular Weight:
205.265
Pathway:
Apoptosis
Purity:
0.98
SMILES:
NC(=N)NC(=N)NCCc1ccccc1
Target:
Apoptosis

References

1. Liu Z, Ren L, Liu C, Xia T, Zha X, Wang S. Phenformin Induces Cell Cycle Change, Apoptosis, and Mesenchymal-Epithelial Transition and Regulates the AMPK/mTOR/p70s6k and MAPK/ERK Pathways in Breast Cancer Cells. PLoS One. 2015 Jun 26;10(6):e0131207. doi: 10.1371/journal.pone.0131207. eCollection 2015. PubMed PMID: 26114294; PubMed Central PMCID: PMC4482683. 2. Yuan P, Ito K, Perez-Lorenzo R, Del Guzzo C, Lee JH, Shen CH, Bosenberg MW, McMahon M, Cantley LC, Zheng B. Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18226-31. doi: 10.1073/pnas.1317577110. Epub 2013 Oct 21. PubMed PMID: 24145418; PubMed Central PMCID: PMC3831456. 3. Krishnamurthy S, Ng VW, Gao S, Tan MH, Yang YY. Phenformin-loaded polymeric micelles for targeting both cancer cells and cancer stem cells in vitro and in vivo. Biomaterials. 2014 Nov;35(33):9177-86. doi: 10.1016/j.biomaterials.2014.07.018. Epub 2014 Aug 5. PubMed PMID: 25106770. 4. Wang J, Xia S, Zhu Z. Synergistic effect of phenformin in non-small cell lung cancer (NSCLC) ionizing radiation treatment. Cell Biochem Biophys. 2015 Mar;71(2):513-8. doi: 10.1007/s12013-014-0283-z. PubMed PMID: 25312480.