Cyclosporin B

Product Code:

TAR-T19848

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

No additional charges, what you see is what you pay! *

Code	Size	Price

TAR-T19848-5mg

5mg

£850.00

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Quantity:

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Further Information

Bioactivity:

Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B into hepatocytes. Cyclosporin B also inhibits RANKL-induced TRAP phosphatase activity, inducing apoptosis in osteoclasts. Cyclosporin B is a derivative of cyclosporin A that exhibits significantly less immunosuppressive activity.

CAS:

63775-95-1

Formula:

C61H109N11O12

Molecular Weight:

1188.608

Purity:

0.98

SMILES:

[H][C@@]1([C@H](O)[C@H](C)CC=CC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](C)NC1=O)C(C)C

Documents

References

1. Jansen Of Lorkeers SJ, Hart E, Tang XL, Chamuleau ME, Doevendans PA, Bolli R, Chamuleau SA. Cyclosporin in cell therapy for cardiac regeneration. J Cardiovasc Transl Res. 2014 Jul;7(5):475-82. doi: 10.1007/s12265-014-9570-8. Epub 2014 May 16. Review. PubMed PMID: 24831573; PubMed Central PMCID: PMC4435776. 2. Penninga L, Penninga EI, M?ller CH, Iversen M, Steinbr?chel DA, Gluud C. Tacrolimus versus cyclosporin as primary immunosuppression for lung transplant recipients. Cochrane Database Syst Rev. 2013 May 31;(5):CD008817. doi: 10.1002/14651858.CD008817.pub2. Review. PubMed PMID: 23728681. 3. Cheng M. Hartmann Stahelin (1925-2011) and the contested history of cyclosporin A. Clin Transplant. 2013 May-Jun;27(3):326-9. doi: 10.1111/ctr.12072. Epub 2013 Jan 20. Review. PubMed PMID: 23331048. 4. Yilmaz M, Eskazan AE, Unsal A, Taninmis H, Kara E, Cetiner M, Ferhanoglu B. Cyclosporin A therapy on idiopathic thrombotic thrombocytopenic purpura in the relapse setting: two case reports and a review of the literature. Transfusion. 2013 Jul;53(7):1586-93. doi: 10.1111/j.1537-2995.2012.03944.x. Epub 2012 Nov 1. Review. PubMed PMID: 23121663.