TargetMol

TAK-632

Product Code:
 
TAR-T1886
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1886-5mg5mg£99.00
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TAR-T1886-10mg10mg£107.00
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TAR-T1886-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T1886-25mg25mg£133.00
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TAR-T1886-50mg50mg£172.00
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TAR-T1886-100mg100mg£250.00
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TAR-T1886-200mg200mg£303.00
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This product comes from: United States.
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Further Information

Bioactivity:
TAK-632 is a potent pan-Raf inhibitor.
CAS:
1228591-30-7
Formula:
C27H18F4N4O3S
Molecular Weight:
554.52
Pathway:
Tyrosine Kinase/Adaptors; Cell Cycle/Checkpoint; Angiogenesis; MAPK; Chromatin/Epigenetic
Purity:
0.9927
SMILES:
Fc1ccc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2C#N)cc1NC(=O)Cc1cccc(c1)C(F)(F)F
Target:
Raf; FGFR; PDGFR; Aurora Kinase

References

1. Okaniwa M, et al. J Med Chem. 2013, 56(16), 6478-6494. 2. Nakamura A, et al. Cancer Res. 2013, 73(23), 7043-7055. 3. Zhang H, Xu L, Qin X, et al. N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl) phenyl) acetamido) phenoxy) benzo [d] thiazol-2-yl) cyclopropanecarboxamide (TAK-632) Analogues as Novel Necroptosis Inhibitors by Targeting Receptor-Interacting Protein Kinase 3 (RIPK3): Synthesis, Structure-Activity Relationships and In Vivo Efficacy[J]. Journal of Medicinal Chemistry. 2019 May 28.