Rebeccamycin

Product Code:

TAR-T16726

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T16726-5mg

5mg

£850.00

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Quantity:

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Further Information

Bioactivity:

Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.

CAS:

93908-02-2

Formula:

C27H21Cl2N3O7

Molecular Weight:

570.38

Pathway:

DNA Damage/DNA Repair

Purity:

0.98

SMILES:

CO[C@@H]1[C@@H](CO)O[C@H]([C@H](O)[C@H]1O)n1c2c(Cl)cccc2c2c3C(=O)NC(=O)c3c3c4cccc(Cl)c4[nH]c3c12

Target:

Topoisomerase

Documents

References

1. Merchant J, et al. Phase I clinical and pharmacokinetic study of NSC 655649, a rebeccamycin analogue, given in both single-dose and multiple-dose formats. Clin Cancer Res. 2002 Jul;8(7):2193-201. 2. Bush JA, et al. Production and biological activity of rebeccamycin, a novel antitumor agent. J Antibiot (Tokyo). 1987 May;40(5):668-78. 3. S?nchez C, et al. The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives. Chem Biol. 2002 Apr;9(4):519-31.