TargetMol

NSC-87877

Product Code:
 
TAR-T16350
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16350-5mg5mg£108.00
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Quantity:
TAR-T16350-1mL1 mL * 10 mM (in DMSO)£112.00
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TAR-T16350-10mg10mg£135.00
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TAR-T16350-25mg25mg£201.00
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TAR-T16350-50mg50mg£302.00
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Quantity:
TAR-T16350-100mg100mg£464.00
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Further Information

Bioactivity:
NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).
CAS:
56990-57-9
Formula:
C19H13N3O7S2
Molecular Weight:
459.45
Pathway:
Apoptosis; Metabolism
Purity:
1
SMILES:
Oc1c(cc(c2cccnc12)S(O)(=O)=O)N=Nc1ccc2cc(ccc2c1)S(O)(=O)=O
Target:
Apoptosis; Phosphatase

References

1. Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. 2. Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5.