TargetMol

MK-0674

Product Code:
 
TAR-T16089
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16089-5mg5mg£1,251.00
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TAR-T16089-50mg50mg£2,464.00
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Quantity:
TAR-T16089-100mg100mg£3,283.00
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This product comes from: United States.
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Further Information

Bioactivity:
MK-0674 is an effective and selective cathepsin K inhibitor (IC50: 0.4 nM). It also displays 1156, 1465, 11857, and 243 fold selectivity over Cat B, Cat F, Cat L, and Cat S.
CAS:
887781-62-6
Formula:
C26H27F6N3O2
Molecular Weight:
527.511
Pathway:
Apoptosis
Purity:
0.98
SMILES:
CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)[C@@H](O)C(F)F)C(F)(F)F)C(=O)NC1(CC1)C#N
Target:
BCL

References

1. Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20(3):887-92.