TargetMol

Nevirapine

Product Code:
 
TAR-T1595
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1595-5mg5mg£95.00
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Quantity:
TAR-T1595-1mL1 mL * 10 mM (in DMSO)£111.00
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Quantity:
TAR-T1595-10mg10mg£111.00
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Quantity:
TAR-T1595-50mg50mg£118.00
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Quantity:
TAR-T1595-100mg100mg£136.00
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Quantity:
TAR-T1595-200mg200mg£142.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
Nevirapine is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral loads and increases CD4 counts, thereby retarding or preventing the damage to the immune system and reducing the risk of developing AIDS.
CAS:
129618-40-2
Formula:
C15H14N4O
Molecular Weight:
266.304
Pathway:
Microbiology/Virology; Proteases/Proteasome
Purity:
0.996
SMILES:
Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12
Target:
HIV Protease; Reverse Transcriptase

References

1. Erickson DA, et al. Drug Metab Dispos, 1999, 27(12), 1488-1495. 10. Zhang R, Zhang F, Sun Z, et al. LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor Suppressor Gene FGGY[J]. Cancer research. 2019: canres. 0076.2019. 2. Mangiacasale R, et al. Oncogene, 2003, 22(18), 2750-2761. 3. Grob PM, et al. AIDS Res Hum Retroviruses, 1992, 8(2), 145-152. 4. Palaniappan C, et al. J Biol Chem, 1995, 270(9), 4861-4869. 5. Riska PS, et al. Drug Metab Dispos, 1999, 27(12), 1434-1447. 6. Onasanwo SA, et al. Evaluation of anti-ulcerogenic and ulcer-healing activities of nevirapine in rats. Afr J Med Med Sci. 2015 Sep;44(3):251-9. 7. Wu Y, Yang J, Duan C, et al. Simultaneous determination of antiretroviral drugs in human hair with liquid chromatography-electrospray ionization-tandem mass spectrometry[J]. Journal of Chromatography B. 2018 Apr 15;1083:209-221. 8. Tan S, Li W, Li Z, et al. A Novel CXCR4 Targeting Protein SDF-1/54 as an HIV-1 Entry Inhibitor. Viruses. 2019, 11(9): 874. 9. Tan S, Li J Q, Cheng H, et al. The anti-parasitic drug suramin potently inhibits formation of seminal amyloid fibrils and their interaction with HIV-1[J]. Journal of Biological Chemistry. 2019: jbc. RA118. 006797.