TargetMol

M-525

Product Code:
 
TAR-T15831
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15831-5mg5mg£1,332.00
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Quantity:
TAR-T15831-50mg50mg£2,625.00
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Quantity:
TAR-T15831-100mg100mg£3,524.00
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This product comes from: United States.
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Further Information

Bioactivity:
M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, irreversible, and covalent menin-MLL protein-protein interaction inhibitor. It has an Anti-leukemia activity.
CAS:
2173582-08-4
Formula:
C39H51FN6O5S
Molecular Weight:
734.93
Purity:
0.98
SMILES:
COC(=O)N[C@H]1CCC[C@@H]1[C@@](C#N)(C1CCN(CC2CN(C2)c2ccc(cc2)S(=O)(=O)C2CN(C2)C(=O)C=CCN(C)C)CC1)c1cccc(F)c1

References

1. Xu S, et al. Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605.