TargetMol

Iodophenpropit dihydrobromide

Product Code:
 
TAR-T15590
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15590-5mg5mg£850.00
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TAR-T15590-50mg50mg£1,661.00
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TAR-T15590-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Iodophenpropit dihydrobromide is an effective and selective antagonist of the histamine H3 receptor. The binding of [125I]Iodophenpropit is readily reversible, selective, and of high affinity (KD: 0.32 nM).
CAS:
145196-87-8
Formula:
C15H21Br2IN4S
Molecular Weight:
576.13
Pathway:
Neuroscience; Immunology/Inflammation; GPCR/G Protein
Purity:
0.98
SMILES:
Br.Br.Ic1ccc(CCNC(=N)SCCCc2c[nH]cn2)cc1
Target:
Histamine Receptor

References

1. Jansen FP, et al. The first radiolabeled histamine H3 receptor antagonist, [ 2. Leurs R, et al. Evaluation of the receptor selectivity of the H3 receptor antagonists, Iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed. Br J Pharmacol. 1995 Oct;116(4):2315-21. 3. Allen MC. Agonist and antagonist effects of histamine H3 receptor ligands on 5-HT3 receptor-mediated ion currents in NG108-15 cells. Eur J Pharmacol. 1998 Nov 20;361(2-3):261-8. 4. Trivendra Tripathi, et al. In vivo immunomodulatory profile of histamine receptors (H1, H2, H3 and H4): a comparative antagonists study. Asian Pac J Trop Med. 2010 Jun;3(6):465-470.