TargetMol

Intoplicine

Product Code:
 
TAR-T15586
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15586-5mg5mg£604.00
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Quantity:
TAR-T15586-50mg50mg£2,464.00
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Quantity:
TAR-T15586-100mg100mg£3,283.00
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This product comes from: United States.
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Further Information

Bioactivity:
Intoplicine is an inhibitor of DNA topoisomerase I and II.
CAS:
125974-72-3
Formula:
C21H24N4O
Molecular Weight:
348.45
Pathway:
DNA Damage/DNA Repair
Purity:
0.98
SMILES:
CN(C)CCCNc1ncc(C)c2[nH]c3ccc4cc(O)ccc4c3c12
Target:
Topoisomerase

References

1. Eckardt JR, et al. Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst. 1994 Jan 5;86(1):30-3. 2. Morjani H, et al. Molecular and cellular interactions between Intoplicine, DNA, and topoisomerase II studied by surface-enhanced Raman scattering spectroscopy. Cancer Res. 1993 Oct 15;53(20):4784-90.