TargetMol

GSK-7975A

Product Code:
 
TAR-T15423
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15423-1mg1mg£107.00
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TAR-T15423-5mg5mg£149.00
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TAR-T15423-1mL1 mL * 10 mM (in DMSO)£180.00
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TAR-T15423-10mg10mg£197.00
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TAR-T15423-25mg25mg£340.00
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TAR-T15423-50mg50mg£529.00
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Quantity:
TAR-T15423-100mg100mg£728.00
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This product comes from: United States.
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Further Information

Bioactivity:
GSK-7975A is a potent and orally available inhibitor of CRAC channel.
CAS:
1253186-56-9
Formula:
C18H12F5N3O2
Molecular Weight:
397.305
Pathway:
Membrane transporter/Ion channel; Metabolism
Purity:
0.9978
SMILES:
Oc1ccc(Cn2ccc(NC(=O)c3c(F)cccc3F)n2)c(c1)C(F)(F)F
Target:
Calcium Channel

References

1. Ashmole I, et al. CRACM/Orai ion channel expression and function in human lung mast cells. J Allergy Clin Immunol. 2012 Jun;129(6):1628-35.e2. 2. Rice LV, et al. Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57. 3. Wen L, et al. Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. Gastroenterology. 2015 Aug;149(2):481-92.e7.