TargetMol

Fluorofenidone

Product Code:
 
TAR-T15300
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15300-1mg1mg£103.00
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TAR-T15300-2mg2mg£118.00
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TAR-T15300-1mL1 mL * 10 mM (in DMSO)£143.00
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TAR-T15300-5mg5mg£148.00
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TAR-T15300-10mg10mg£201.00
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TAR-T15300-25mg25mg£334.00
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TAR-T15300-50mg50mg£529.00
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TAR-T15300-100mg100mg£728.00
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TAR-T15300-500mg500mg£1,428.00
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Further Information

Bioactivity:
Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an analogue of AMR69. Which displays equivalent lower toxicity, antifibrotic activity, and longer half-life.
CAS:
848353-85-5
Formula:
C12H10FNO
Molecular Weight:
203.216
Purity:
0.9987
SMILES:
Cc1ccc(=O)n(c1)-c1cccc(F)c1

References

1. Qin J, et al. Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Nephrology (Carlton). 2013 Oct;18(10):690-9. 2. Lou Q, et al. Design, synthesis and antifibrotic activities of carbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones. Molecules. 2012 Jan 17;17(1):884-96.