TargetMol

DB07107

Product Code:
 
TAR-T15056
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15056-5mg5mg£850.00
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TAR-T15056-50mg50mg£1,661.00
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Quantity:
TAR-T15056-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
DB07107 is a potent inhibitor of drug resistant T315I mutant Bcr-Abl tyrosine kinase and a potent Akt1 inhibitor (IC50: 360 nM).
CAS:
552332-71-5
Formula:
C23H22N4O
Molecular Weight:
370.456
Pathway:
Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
N[C@@H](COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12
Target:
Akt

References

1. Banavath HN, et al. Identification of novel tyrosine kinase inhibitors for drug resistant T315I mutant BCR-ABL: a virtual screening and molecular dynamics simulations study. Sci Rep. 2014 Nov 10;4:6948. 2. Li Q, et al. Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1679-85.