TargetMol

CGP37157

Product Code:
 
TAR-T14941
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14941-5mg5mg£107.00
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TAR-T14941-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T14941-10mg10mg£132.00
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TAR-T14941-25mg25mg£195.00
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TAR-T14941-50mg50mg£280.00
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Quantity:
TAR-T14941-100mg100mg£427.00
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Further Information

Bioactivity:
CGP37157 is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitochondria in guinea pig heart with IC50 of 0.8 μM.
CAS:
75450-34-9
Formula:
C15H11Cl2NOS
Molecular Weight:
324.22
Pathway:
Membrane transporter/Ion channel
Purity:
0.9904
SMILES:
Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1
Target:
Na+/Ca2+ Exchanger

References

1. Chiesi M, et al. Structural dependency of the inhibitory action of benzodiazepines and related compounds on the mitochondrial Na+-Ca2+ exchanger. Biochem Pharmacol. 1988 Nov 15;37(22):4399-403. 2. Scherzed A, et al. Effects of salinomycin and CGP37157 on head and neck squamous cell carcinoma cell lines in vitro. Mol Med Rep. 2015 Sep;12(3):4455-61. 3. Ruiz A, et al. CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels. Cell Death Dis. 2014 Apr 10;5:e1156.