TargetMol

CC0651

Product Code:
 
TAR-T14896
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14896-5mg5mg£854.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T14896-50mg50mg£1,982.00
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Quantity:
TAR-T14896-100mg100mg£2,560.00
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This product comes from: United States.
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Further Information

Bioactivity:
CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. CC0651 potently inhibits the ubiquitination of p27Kip1 (IC50: 1.72 μM).
CAS:
1319207-44-7
Formula:
C20H21Cl2NO6
Molecular Weight:
442.29
Purity:
0.98
SMILES:
COCC(=O)N[C@@H](Cc1ccc(cc1)-c1cc(Cl)cc(Cl)c1)[C@H](O)[C@@H](O)C(O)=O

References

1. Ceccarelli DF, et al. An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell. 2011 Jun 24;145(7):1075-87. 2. Huang H, et al. E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nat Chem Biol. 2014 Feb;10(2):156-63.