TargetMol

BRD6989

Product Code:
 
TAR-T14778
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14778-1mg1mg£95.00
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TAR-T14778-5mg5mg£124.00
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TAR-T14778-1mL1 mL * 10 mM (in DMSO)£133.00
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TAR-T14778-10mg10mg£149.00
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TAR-T14778-25mg25mg£237.00
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TAR-T14778-50mg50mg£367.00
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Quantity:
TAR-T14778-100mg100mg£511.00
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Further Information

Bioactivity:
BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM.
CAS:
642008-81-9
Formula:
C16H16N4
Molecular Weight:
264.332
Pathway:
Cell Cycle/Checkpoint; Immunology/Inflammation
Purity:
0.9882
SMILES:
CC1CCc2nc(N)c(C#N)c(-c3cccnc3)c2C1
Target:
IL Receptor; CDK; Interleukin

References

1. Johannessen L, et al. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017 Oct;13(10):1102-1108