TargetMol

Deucravacitinib

Product Code:
 
TAR-T14687
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14687-1mg1mg£124.00
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TAR-T14687-5mg5mg£197.00
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TAR-T14687-1mL1 mL * 10 mM (in DMSO)£209.00
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TAR-T14687-10mg10mg£304.00
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TAR-T14687-25mg25mg£438.00
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TAR-T14687-50mg50mg£610.00
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TAR-T14687-100mg100mg£838.00
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TAR-T14687-500mg500mg£1,613.00
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Further Information

Bioactivity:
BMS-986165 inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain.
CAS:
1609392-27-9
Formula:
C20H22N8O3
Molecular Weight:
425.467
Pathway:
Immunology/Inflammation; Tyrosine Kinase/Adaptors; JAK/STAT signaling; Stem Cells; Chromatin/Epigenetic; Angiogenesis
Purity:
0.9943
SMILES:
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
Target:
Tyrosine Kinases; JAK; IFNAR; Interleukin

References

1. Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18. 2. Catlett I, et al. SAT0226 A first-in-human, study of BMS-986165, a selective, potent, allosteric small molecule inhibitor of tyrosine kinase 2. Annals of the Rheumatic Diseases 2017;76:859.