TargetMol

Maytansinoid DM4

Product Code:
 
TAR-T13766
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13766-5mg5mg£4,890.00
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Further Information

Bioactivity:
Maytansinoid DM4 can be used as a cytotoxic moiety of ADC. Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity.
CAS:
799840-96-3
Formula:
C39H56ClN3O10S
Molecular Weight:
794.4
Purity:
0.98
SMILES:
[H][C@@]12O[C@@]1(C)[C@H](CC(=O)N(C)c1cc(CC(C)=C/C=C[C@@H](OC)[C@@]3(O)C[C@]([H])(OC(=O)N3)C2(C)C)cc(OC)c1Cl)OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)S

References

1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. 2. Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23.