TargetMol

PF-06733804

Product Code:
 
TAR-T13207
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13207-5mg5mg£1,010.00
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TAR-T13207-50mg50mg£1,982.00
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Quantity:
TAR-T13207-100mg100mg£2,560.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.
CAS:
1873373-33-1
Formula:
C20H19F5N4O4
Molecular Weight:
474.388
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
CNC(=O)c1cnc(N)c(O[C@H]2CN(CC2(F)F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1
Target:
Trk receptor

References

1. Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800.