TargetMol

(S)-3-Hydroxy Midostaurin

Product Code:
 
TAR-T12791
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12791-5mg5mg£2,135.00
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Quantity:
TAR-T12791-50mg50mg£4,231.00
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Quantity:
TAR-T12791-100mg100mg£5,934.00
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This product comes from: United States.
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Further Information

Bioactivity:
(S)-3-Hydroxy Midostaurin is a potent inhibitor of kinases(IC50 of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et)).
CAS:
945260-14-0
Formula:
C35H30N4O5
Molecular Weight:
586.648
Purity:
0.98
SMILES:
CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1

References

1. Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590.