TargetMol

RPR107393 free base

Product Code:
 
TAR-T12765
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12765-5mg5mg£850.00
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TAR-T12765-50mg50mg£1,661.00
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Quantity:
TAR-T12765-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
RPR107393 free base is a selective inhibitor of squalene synthase(rat liver microsomal squalene synthase, with an IC50 of 0.8 nM).
CAS:
197576-78-6
Formula:
C22H22N2O
Molecular Weight:
330.431
Purity:
0.98
SMILES:
OC1(CN2CCC1CC2)c1ccc(cc1)-c1ccc2ncccc2c1

References

1. Amin D, et al. RPR107393, a potent squalene synthase inhibitor and orally effective Cholesterol-lowering agent: comparison with inhibitors of HMG-CoA reductase. J Pharmacol Exp Ther. 1997 May;281(2):746-52. 2. Hiyoshi H, et al. Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes. J Lipid Res. 2003 Jan;44(1):128-35.