TargetMol

RORγt Inverse agonist 2

Product Code:
 
TAR-T12755
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12755-5mg5mg£1,251.00
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TAR-T12755-50mg50mg£2,464.00
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TAR-T12755-100mg100mg£3,283.00
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Further Information

Bioactivity:
RORγt Inverse agonist 2 is a selective, orally active inverse agonist of RORγt(EC50 of 119 nM).
CAS:
1801197-92-1
Formula:
C27H25F8NO5S
Molecular Weight:
627.55
Purity:
0.98
SMILES:
OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@](C1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1

References

1. Duan JJ, et al. Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active ROR?t Inverse Agonists. ACS Med Chem Lett. 2019 Feb 26;10(3):367-373.