TargetMol

RORγt Inverse agonist 3

Product Code:
 
TAR-T12752
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12752-5mg5mg£502.00
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TAR-T12752-50mg50mg£1,982.00
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TAR-T12752-100mg100mg£2,560.00
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Further Information

Bioactivity:
RORγt Inverse agonist 3 is a potent, selective and orally active inverse agonist of RORγ(EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively).
CAS:
2364429-77-4
Formula:
C29H31Cl2N5O4S
Molecular Weight:
616.56
Purity:
0.98
SMILES:
CNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(Cl)c(COc2cccc3c(cc(nc23)C(C)C)-c2cncn2C)c1Cl

References

1. Amaudrut J, et al. Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active ROR? inverse agonists. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1799-1806.