TargetMol

(R)-BAY-85-8501

Product Code:
 
TAR-T12613
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12613-200mg200mgEnquire
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TAR-T12613-500mg500mgEnquire
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TAR-T12613-5mg5mg£370.00
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TAR-T12613-10mg10mg£571.00
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TAR-T12613-25mg25mg£1,235.00
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TAR-T12613-50mg50mg£1,468.00
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Quantity:
TAR-T12613-100mg100mg£2,263.00
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Further Information

Bioactivity:
(R)-BAY-85-8501 is the less active enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent Human Neutrophil Elastase (HNE)inhibitor(IC50 of 65 pM).
CAS:
T12613
Formula:
C22H17F3N4O3S
Molecular Weight:
474.46
Purity:
0.98
SMILES:
N#CC1=C(C)N(C2=CC=CC(C(F)(F)F)=C2)C(N(C)[C@H]1C3=CC=C(C#N)C=C3S(=O)(C)=O)=O

References

1. Von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73.