TargetMol

PROTAC BET degrader-2

Product Code:
 
TAR-T12559
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12559-100mg100mgEnquire
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TAR-T12559-50mg50mgEnquire
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TAR-T12559-5mg5mg£390.00
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TAR-T12559-10mg10mg£577.00
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TAR-T12559-1mL1 mL * 10 mM (in DMSO)£582.00
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TAR-T12559-25mg25mg£1,010.00
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This product comes from: United States.
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Further Information

Bioactivity:
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).
CAS:
2093388-33-9
Formula:
C41H42N10O6
Molecular Weight:
770.851
Purity:
0.98
SMILES:
CCn1nc(cc1Nc1nc(nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12)C(=O)NCCCc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O)C1CC1

References

1. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.