TargetMol

PF-04634817

Product Code:
 
TAR-T12419L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T12419L-5mg5mg£1,010.00
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TAR-T12419L-50mg50mg£1,982.00
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Quantity:
TAR-T12419L-100mg100mg£2,560.00
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This product comes from: United States.
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Further Information

Bioactivity:
PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 antagonist. It also has comparable human and rodent CCR2 potency (rat IC50=20.8 nM). PF-0463481 shows 10-20 fold less rodent CCR5 potency (rat IC50=470 nM).
CAS:
1228111-63-4
Formula:
C25H36F3N5O3
Molecular Weight:
511.59
Pathway:
Microbiology/Virology; Immunology/Inflammation
Purity:
0.98
SMILES:
[H][C@]12CN(c3cc(ncn3)C(F)(F)F)[C@]([H])(CN1C(=O)[C@]1(CC[C@H](C1)N[C@H]1CCOC[C@H]1OC)C(C)C)C2
Target:
CCR

References

1. Tesch GH, et al. Combined inhibition of CCR2 and ACE provides added protection against progression of diabetic nephropathy in?Nos3-deficient mice.Am J Physiol Renal Physiol.?2019 Dec 1;317(6):F1439-F1449. 2. Gale JD, et al. A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema. Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2659-2669. 3. Gale JD, et al. Effect of PF-04634817, an Oral CCR2/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy. Kidney Int Rep. 2018 Aug 3;3(6):1316-1327.