TargetMol

Mcl1-IN-9

Product Code:
 
TAR-T11977
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11977-5mg5mg£930.00
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TAR-T11977-50mg50mg£1,821.00
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Quantity:
TAR-T11977-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.
CAS:
1810769-31-3
Formula:
C37H39ClN4O4
Molecular Weight:
639.19
Pathway:
Apoptosis
Purity:
0.98
SMILES:
Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c3C(=O)N(Cc4cccc(c4)C(O)=O)CCCn3c12
Target:
BCL

References

1. Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62(8):3971-3988.