TargetMol

JTE-952

Product Code:
 
TAR-T11729
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11729-5mg5mg£401.00
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TAR-T11729-50mg50mg£1,830.00
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TAR-T11729-100mg100mg£2,560.00
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This product comes from: United States.
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Further Information

Bioactivity:
JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.
CAS:
1255303-54-8
Formula:
C30H34N2O6
Molecular Weight:
518.61
Pathway:
GPCR/G Protein; Immunology/Inflammation; Neuroscience
Purity:
0.98
SMILES:
COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COC[C@@H](O)CO)ccn1
Target:
Histamine Receptor

References

1. Ikegashira K, et al. Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952. Bioorg Med Chem Lett. 2019 Apr 1;29(7):873-877.