TargetMol

IDH1 Inhibitor 2

Product Code:
 
TAR-T11611
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11611-5mg5mg£870.00
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TAR-T11611-50mg50mg£2,143.00
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Quantity:
TAR-T11611-100mg100mg£2,801.00
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This product comes from: United States.
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Further Information

Bioactivity:
IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).
CAS:
2244895-42-7
Formula:
C26H22N4O
Molecular Weight:
406.489
Pathway:
Metabolism
Purity:
0.98
SMILES:
[H][C@@]12CCc3cnc(Nc4ccccc4)nc3[C@]1(C=C(C#N)C(=O)[C@H]2C)c1ccccc1
Target:
Dehydrogenase

References

1. Jakob CG, et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018 Aug 9;61(15):6647-6657.