TargetMol

GB-110 hydrochloride (1252806-70-4 free base)

Product Code:
 
TAR-T11369L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11369L-200mg200mgEnquire
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TAR-T11369L-500mg500mgEnquire
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TAR-T11369L-5mg5mg£320.00
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TAR-T11369L-1mL1 mL * 10 mM (in DMSO)£425.00
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TAR-T11369L-10mg10mg£461.00
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TAR-T11369L-25mg25mg£772.00
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TAR-T11369L-50mg50mg£1,238.00
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TAR-T11369L-100mg100mg£1,662.00
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Further Information

Bioactivity:
GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist.
CAS:
T11369L
Formula:
C33H49ClN6O5
Molecular Weight:
645.23
Purity:
0.98
SMILES:
O=C(C1=CC=NO1)N[C@@H](CC2CCCCC2)C(N[C@@H]([C@@H](C)CC)C(NCC3=CC=CC(C(N4CCC(CN)CC4)=O)=C3)=O)=O.Cl

References

1. Barry GD, et al. Novel agonists and antagonists for human protease activated receptor 2. J Med Chem. 2010 Oct 28;53(20):7428-40. 2. Suen JY, et al. Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). Br J Pharmacol. 2012 Mar;165(5):1413-23.