TargetMol

Ethyl tosylcarbamate

Product Code:
 
TAR-T11243
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11243-5mg5mg£850.00
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Further Information

Bioactivity:
Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877).
CAS:
5577-13-9
Formula:
C10H13NO4S
Molecular Weight:
243.28
Purity:
0.98
SMILES:
CCOC(=O)NS(=O)(=O)c1ccc(C)cc1

References

1. Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27(4):301-27. 2. Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57(13), 1476?1478. 3. Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55(6): p. 722-30.