TargetMol

DUPA(OtBu)-OH

Product Code:
 
TAR-T11122
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11122-1mg1mg£122.00
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TAR-T11122-5mg5mg£189.00
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TAR-T11122-1mL1 mL * 10 mM (in DMSO)£201.00
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TAR-T11122-10mg10mg£257.00
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TAR-T11122-25mg25mg£374.00
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TAR-T11122-50mg50mg£505.00
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TAR-T11122-100mg100mg£679.00
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Further Information

Bioactivity:
DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer. PSMA has a high affinity for DUPA(Ki = 8 nM).
CAS:
1026987-94-9
Formula:
C23H40N2O9
Molecular Weight:
488.578
Purity:
0.9974
SMILES:
CC(C)(C)OC(=O)CC[C@H](NC(=O)N[C@@H](CCC(O)=O)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C

References

1. Roy J, et al. DUPA conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selectiveprostate cancer cell targeting. J Med Chem. 2015 Apr 9;58(7):3094-103. 2. Lv Q, et al. Prostate-Specific Membrane Antigen Targeted Therapy of Prostate Cancer Using a DUPA-Paclitaxel Conjugate. Mol Pharm. 2018 May 7;15(5):1842-1852. 3. Peng ZH, et al. Spacer length impacts the efficacy of targeted docetaxel conjugates in prostate-specificmembrane antigen expressing prostate cancer. J Drug Target. 2013 Dec;21(10):968-80.