TargetMol

BGB-102

Product Code:
 
TAR-T10531
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10531-5mg5mg£1,010.00
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TAR-T10531-50mg50mg£1,982.00
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Quantity:
TAR-T10531-100mg100mg£2,560.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 nM, and 40.3 nM).
CAS:
807640-87-5
Formula:
C22H25BrN4O2
Molecular Weight:
457.372
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling
Purity:
0.98
SMILES:
COc1cc2N=CNC3=N/c4cc(Br)ccc4CN(C)CCCCCOc1cc23
Target:
EGFR; HER

References

1. Gijsen M, et al. HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol. 2010 Dec 21;8(12):e1000563.