TargetMol

β3-AR agonist 1

Product Code:
 
TAR-T10523
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10523-5mg5mg£1,091.00
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TAR-T10523-50mg50mg£2,143.00
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Quantity:
TAR-T10523-100mg100mg£2,801.00
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This product comes from: United States.
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Further Information

Bioactivity:
β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold).
CAS:
1283125-73-4
Formula:
C22H28N4O4S
Molecular Weight:
444.55
Purity:
0.98
SMILES:
Cc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(=O)(=O)C4CCC4)c3)ccc12

References

1. Wada Y, et al. Discovery of Novel Indazole Derivatives as Orally Available ?3-Adrenergic Receptor Agonists Lacking Off-Target-Based Cardiovascular Side Effects. J Med Chem. 2017 Apr 27;60(8):3252-3265.