TargetMol

ALK/ROS1-IN-1

Product Code:
 
TAR-T10286
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10286-5mg5mg£850.00
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TAR-T10286-50mg50mg£1,661.00
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Quantity:
TAR-T10286-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).
CAS:
2365497-07-8
Formula:
C30H35F3N6O3
Molecular Weight:
584.644
Purity:
0.98
SMILES:
COc1cc(ccc1Nc1cc(ccn1)N1CCC[C@@H](C1)C(=O)NCc1ccc(OC(F)(F)F)cc1)N1CCNCC1

References

1. Liu S, et al. Design, synthesis and biological evaluations of 2-amino-4-(1-piperidine) pyridine derivatives as novel anti crizotinib-resistant ALK/ROS1 dual inhibitors. Eur J Med Chem. 2019 Oct 1;179:358-375.