TargetMol

AFP464 free base

Product Code:
 
TAR-T10258
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10258-5mg5mg£1,332.00
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TAR-T10258-50mg50mg£2,625.00
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Quantity:
TAR-T10258-100mg100mg£3,524.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.
CAS:
468719-52-0
Formula:
C22H23F3N4O3
Molecular Weight:
448.446
Pathway:
Angiogenesis; Chromatin/Epigenetic
Purity:
0.98
SMILES:
Cc1c(F)c(N)c2c(oc(cc2=O)-c2ccc(NC(=O)[C@@H](N)CCCCN)c(F)c2)c1F
Target:
HIF

References

1. Terzuoli E1, Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010 Sep 1;70(17):6837-48.