TargetMol

Resatorvid

Product Code:
 
TAR-TQ0181
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0181-1mg1mg£107.00
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TAR-TQ0181-2mg2mg£122.00
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TAR-TQ0181-5mg5mg£148.00
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TAR-TQ0181-1mL1 mL * 10 mM (in DMSO)£165.00
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TAR-TQ0181-10mg10mg£205.00
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TAR-TQ0181-25mg25mg£309.00
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TAR-TQ0181-50mg50mg£495.00
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TAR-TQ0181-100mg100mg£688.00
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Further Information

Bioactivity:
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 nM).
CAS:
243984-11-4
Formula:
C15H17ClFNO4S
Molecular Weight:
361.81
Pathway:
Apoptosis; Immunology/Inflammation; Autophagy
Purity:
1
SMILES:
CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)Nc1ccc(F)cc1Cl
Target:
TNF; TLR; Autophagy; Interleukin

References

Ii M, et al. A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. Mol Pharmacol, 69 (4), 1288-95, Apr 2006. Luo D, Han L, Gao S, et al. LINCS Dataset-Based Repositioning of Dutasteride as an Anti-Neuroinflammation Agent. Brain Sciences. 2021, 11(11): 1411. Ni JQ, et al. Role of toll-like receptor 4 on lupus lung injury and atherosclerosis in LPS-challenge ApoE?/? mice. Clin Dev Immunol. 2013;2013:476856. Chen J, Zhao L, Ding X, et al. A?1?40 Oligomers Trigger Neutrophil Extracellular Trap Formation through TLR4- and NADPH Oxidase-Dependent Pathways in Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity. 2022