TargetMol

CDDO-Im

Product Code:
 
TAR-TQ0120
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0120-1mg1mg£95.00
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TAR-TQ0120-5mg5mg£128.00
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TAR-TQ0120-1mL1 mL * 10 mM (in DMSO)£140.00
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TAR-TQ0120-10mg10mg£161.00
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TAR-TQ0120-25mg25mg£249.00
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TAR-TQ0120-50mg50mg£356.00
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TAR-TQ0120-100mg100mg£503.00
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TAR-TQ0120-500mg500mg£994.00
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Further Information

Bioactivity:
CDDO-Im is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
CAS:
443104-02-7
Formula:
C34H43N3O3
Molecular Weight:
541.736
Pathway:
DNA Damage/DNA Repair; Immunology/Inflammation; Apoptosis; Cell Cycle/Checkpoint; ; Metabolism
Purity:
0.983
SMILES:
CC1(C)CC[C@@]2(CC[C@]3(C)[C@@H]([C@@H]2C1)C(=O)C=C1[C@@]2(C)C=C(C#N)C(=O)C(C)(C)[C@@H]2CC[C@@]31C)C(=O)n1ccnc1
Target:
Ferroptosis; Nrf2; PPAR

References

Liby K, et al. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Res. 2005 Jun 1;65(11):4789-98. Place AE, et al. The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clin Cancer Res. 2003 Jul;9(7):2798-806. So JY, et al. A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer. PLoS One. 2014 Sep 17;9(9):e107616.