TargetMol

Brepocitinib

Product Code:
 
TAR-TQ0010
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0010-1mg1mg£101.00
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TAR-TQ0010-2mg2mg£114.00
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TAR-TQ0010-5mg5mg£142.00
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TAR-TQ0010-1mL1 mL * 10 mM (in DMSO)£166.00
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TAR-TQ0010-10mg10mg£189.00
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TAR-TQ0010-25mg25mg£322.00
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TAR-TQ0010-50mg50mg£454.00
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TAR-TQ0010-100mg100mg£623.00
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TAR-TQ0010-200mg200mg£839.00
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This product comes from: United States.
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Further Information

Bioactivity:
Brepocitinib is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).
CAS:
1883299-62-4
Formula:
C18H21F2N7O
Molecular Weight:
389.411
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
Purity:
0.98
SMILES:
Cn1cc(Nc2nccc(n2)N2CC3CCC(C2)N3C(=O)[C@@H]2CC2(F)F)cn1
Target:
Tyrosine Kinases; JAK

References

Fensome A, et al. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J Med Chem. 2018 Oct 11;61(19):8597-8612.