TargetMol

BC-LI-0186

Product Code:
 
TAR-T9533
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9533-1mg1mg£95.00
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TAR-T9533-2mg2mg£106.00
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TAR-T9533-5mg5mg£128.00
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TAR-T9533-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T9533-10mg10mg£168.00
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TAR-T9533-25mg25mg£289.00
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TAR-T9533-50mg50mg£414.00
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TAR-T9533-100mg100mg£584.00
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Further Information

Bioactivity:
BC-LI-0186 is a potent and selective inhibitor of the interaction of Leucyl-tRNA synthetase (LRS) and Ras-related GTP-binding protein D (RagD) with IC50 of 46.11 nM. BC-LI-0186 competitively binds the RagD interaction site of LRS with Kd of 42.1 nM and has no effect on LRS-vps34, LRS-eprs, RagB-RagD association, mTORC1 complex formation. BC-LI-0186 potently inhibits the activity of tumor-associated MTOR mutants and the growth of rapamycin-resistant cancer cells. BC-LI-0186 can be used for lung cancer-related research.
CAS:
695207-56-8
Formula:
C44H53N6O8S2
Molecular Weight:
858.06
Purity:
0.98
SMILES:
CC(C)C(C1=O)=C(C)N(C)N1c(cc1)ccc1S(NCCOc1ccccc1)(=O)=OCC(C)C(C1=O)=C(C)N(C)N1c(cc1)ccc1S(NCCOc1ccccc1)(=O)=O

References

Choi H, Son JB, Kang J, Kwon J, Kim JH, Jung M, Kim SK, Kim S, Mun JY. Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane. Biochem Biophys Res Commun. 2017 Nov 18;493(2):1129-1135. Jong Hyun Kim, et al. Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction. Nat Commun. 2017 Sep 29;8(1):732. Lee M, Kim JH, Yoon I, Lee C, Fallahi Sichani M, Kang JS, Kang J, Guo M, Lee KY, Han G, Kim S, Han JM. Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5279-E5288.